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18-II-19

P. Schröder, A. Wagner, D. Stöhr, M. Rehm, A. Jensch, N. Radde & W. Ehlers

Modelling of lung‐metastases apoptosis within brain tissue

Apoptosis, a form of programmed cell death, can be induced in lung‐cancer cells by treatment with death‐receptor ligands. In this contribution, the coupled multiphasic process is described using a continuum‐mechanical model based on the Theory of Porous Media. Furthermore, the data‐enriched model incorporates the crucial apoptosis parameters, which are estimated via the maximum likelihood estimation based on cell‐culture experiments.


18-II-19
P. Schröder, A. Wagner, D. Stöhr, M. Rehm, A. Jensch, N. Radde & W. Ehlers
Modelling of lung‐metastases apoptosis within brain tissue. Proceedings in Applied Mathematics and Mechanics 18 (2018), DOI: https://doi.org/10.1002/pamm.201800323.